LEPTON GREEN TEA TRIAL
This trial was registered at as NCT04488731.ĭiabetes is hallmarked by high blood glucose levels, which cause progressive generalised vascular damage, leading to microvascular and macrovascular complications. However, overweight was associated with higher leptin, lower vitamin B12, and no change in folic acid levels. There was no possible synergistic effect between body weight and coffee consumption rate on leptin, vitamin B12, or folic acid levels. Finally, the combination of body weight and coffee consumption had no significant effect on leptin, vitamin B12, or folic acid. Coffee consumption rate had no significant effect on leptin, vitamin B12, or folic acid. Body weight was positively associated with leptin (p = 0.00), negatively associated with vitamin B12 (p = 0.047), and not associated with folic acid (p = 0.235). While, the serum levels of folic acid were 8.92, 10.27, 10.12, 10.47 ng/mL, respectively. Serum levels of leptin in NW/MCC, NW/HCC, OW/MCC, OW/HCC groups were 5.93, 5.75, 14.86, 16.79 ng/mL, respectively. Healthy males (n = 122) aged 18 to 26 years continued participation in this study. Serum samples were taken to measure leptin, vitamin B12, and folic acid levels in addition to morning and midnight salivary cortisol and dehydroepiandrosterone (DHEA) samples.
Depending on BMI and extent of coffee consumption, participants were divided into 4 groups normal body weight and moderate coffee consumption (NW/MCC) group normal body weight and heavy coffee consumption (NW/HCC) group overweight and moderate coffee consumption (OW/MCC) group overweight and heavy coffee consumption (OW/HCC) group. Young healthy males were invited to participate in the study and fill a questionnaire regarding lifestyle habits including coffee consumption during the last 3 months, medical history, and anthropometric measurements. This observational cross-sectional study was carried out at the faculty of pharmacy, Applied Science Private University (ASU), Amman, Jordan, from July to September 2020. This study investigates the effect of body weight and/or coffee consumption rate on the serum levels of these molecules in healthy young adult males. Studies on the effect of body weight and coffee consumption on leptin, vitamin B12, and folic acid are scarce and conflicting. More longitudinal investigations should be conducted in this regard to declare these associations. Fewer studies are conducted about the association between these beverages and leptin, and their results are controversial. However, most of them reported the positive role of green tea in adiponectin concentration. Different studies showed contradictory results regarding green tea and adiponectin level.
Several findings suggested the positive association between coffee and adiponectin level. Finally, most related articles were recruited in this regard. We searched in PubMed to January 2013 using several key words such as coffee, green tea, caffeine, leptin, adiponectin, and adipokines. In the present study, we aimed to review the evidence about relationship between these beverages and adiponectin and leptin levels. Adiponectin and leptin are the adipokines mostly secreted from adipose tissue and play the important roles on the status of chronic diseases. Coffee and green tea have significantly inverse correlation with obesity, diabetes, and cardiovascular diseases.
Coffee and green tea are two of most usual consumed beverages in the world which have several benefit components.
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